3-Chloro-4-fluoroaniline → N-(3-Chloro-4-fluorophenyl)-1H-benzimidazol-2-amine

HRID 2423041Notes

Reaction equation

HRID 2423041 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[Cl:11][C:12]1[CH:13]=[C:14]([CH:16]=[CH:17][C:18]=1[F:19])[NH2:15]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:15][C:14]1[CH:16]=[CH:17][C:18]([F:19])=[C:12]([Cl:11])[CH:13]=1

Participants

3

Reactant 2

HCID 97083-Chloro-4-fluoroanilineHCID 785722-Chlorobenzimidazole

Product 1

HCID 15604441N-(3-Chloro-4-fluorophenyl)-1H-benzimidazol-2-amine

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 3-chloro-4-fluoroaniline by Procedure A. The product was isolated by filtration to give the title compound as a hydrochloride salt (white solid, mp 306-307° C.). MS(ES+) m/z 262 ([M+1]+, 100).

Workup

  1. customThe product was isolated by filtration

Sources & evidence

ORD record
ord-a7a735dab62b4259a74657e74578362b
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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