4-Bromo-3-(trifluoromethyl)aniline → N-[4-Bromo-3-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

HRID 2423043Notes

Reaction equation

HRID 2423043 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[Br:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][C:13]=1[C:19]([F:22])([F:21])[F:20]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:16][C:15]1[CH:17]=[CH:18][C:12]([Br:11])=[C:13]([C:19]([F:22])([F:20])[F:21])[CH:14]=1

Participants

3

Reactant 2

HCID 678524-Bromo-3-(trifluoromethyl)anilineHCID 785722-Chlorobenzimidazole

Product 1

HCID 15602779N-[4-Bromo-3-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 4-bromo-3-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration to give the title compound as a hydrochloride salt (white solid, mp 262-264° C.). MS(ES+) m/z 356 (M+, 100).

Workup

  1. customThe product was isolated by filtration

Sources & evidence

ORD record
ord-e1994f61d11b4a96955b11ea1adf9269
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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