2-Chlorobenzimidazole → N-[3-Fluoro-5-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

HRID 2423045Notes

Reaction equation

HRID 2423045 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]1[CH:13]=[C:14]([CH:16]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:18]=1)[NH2:15]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:15][C:14]1[CH:16]=[C:17]([C:19]([F:20])([F:21])[F:22])[CH:18]=[C:12]([F:11])[CH:13]=1

Participants

3

Reactant 2

HCID 785722-ChlorobenzimidazoleHCID 27359133-Amino-5-fluorobenzotrifluoride

Product 1

HCID 15602781N-[3-Fluoro-5-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 3-fluoro-5-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration to give the title compound as a hydrochloride salt (white solid, mp 263-265° C.). MS(ES+) m/z 296 ([M+1]+, 100).

Workup

  1. customThe product was isolated by filtration

Sources & evidence

ORD record
ord-ef9e6539457e4c479073b2ab66ebaea3
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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