2,3,4-Trifluoroaniline → N-(2,3,4-Trifluorophenyl)-1H-benzimidazol-2-amine

HRID 2423048Notes

Reaction equation

HRID 2423048 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]1[C:18]([F:19])=[C:17]([F:20])[CH:16]=[CH:15][C:13]=1[NH2:14]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:14][C:13]1[CH:15]=[CH:16][C:17]([F:20])=[C:18]([F:19])[C:12]=1[F:11]

Participants

3

Reactant 2

HCID 774682,3,4-TrifluoroanilineHCID 785722-Chlorobenzimidazole

Product 1

HCID 15602784N-(2,3,4-Trifluorophenyl)-1H-benzimidazol-2-amine

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 2,3,4-trifluoroaniline by Procedure A. The product was isolated by filtration and preparative LCMS to give the title compound as the free base (white solid, mp 182-183° C.). MS(ES+) m/z 264 ([M+1]+, 100).

Workup

  1. customThe product was isolated by filtration and preparative LCMS

Sources & evidence

ORD record
ord-debaacbeaa3341f486c04cd22741d8e3
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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