3-Aminobenzonitrile → 3-[(1H-Benzimidazol-2-yl)amino]benzonitrile

HRID 2423049Notes

Reaction equation

HRID 2423049 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH2:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[C:15]#[N:16]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:11][C:12]1[CH:19]=[CH:18][CH:17]=[C:14]([C:15]#[N:16])[CH:13]=1

Participants

3

Reactant 2

HCID 167023-AminobenzonitrileHCID 785722-Chlorobenzimidazole

Product 1

HCID 156027863-[(1H-Benzimidazol-2-yl)amino]benzonitrile

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 3-aminobenzonitrile by Procedure A. The product was isolated by filtration and preparative LCMS to give the title compound as the free base (white solid, mp 272-274° C.). MS(ES+) m/z 235 ([M+1]+, 100).

Workup

  1. customThe product was isolated by filtration and preparative LCMS

Sources & evidence

ORD record
ord-25b64aee81f440588a0155b02c69c9b5
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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