2-Chlorobenzimidazole → N-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

HRID 2423050Notes

Reaction equation

HRID 2423050 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:17]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:19]=1)[NH2:16]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:16][C:15]1[CH:17]=[C:18]([C:20]([F:22])([F:23])[F:21])[CH:19]=[C:13]([O:12][CH3:11])[CH:14]=1

Participants

3

Reactant 2

HCID 785722-ChlorobenzimidazoleHCID 6056715-(Trifluoromethyl)-m-anisidine

Product 1

HCID 15602787N-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 3-methoxy-5-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration to give the title compound as a hydrochloride salt (white solid, mp 212-213° C.). MS(ES+) m/z 308 ([M+1]+, 100).

Workup

  1. customThe product was isolated by filtration

Sources & evidence

ORD record
ord-67ead7b83b164e1cb7315199b71649a0
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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