Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2423050Generated: October 27, 2026

2-Chlorobenzimidazole → N-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

https://huagongshe.com/reaction/2423050

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-ChlorobenzimidazoleHCID 78572—
Reactant5-(Trifluoromethyl)-m-anisidineHCID 605671—
ProductN-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amineHCID 15602787—

Reaction Steps

The title compound was prepared from 2-chlorobenzimidazole and 3-methoxy-5-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration to give the title compound as a hydrochloride salt (white solid, mp 212-213° C.). MS(ES+) m/z 308 ([M+1]+, 100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960561B2
Source datasetuspto-grants-2011_06
ORD IDord-67ead7b83b164e1cb7315199b71649a0
Source noteuspto-grants-2011_06