Benzenamine, 2-chloro-5-(trifluoromethyl)- → HCID 923997, compound

HRID 2423052Notes

Reaction equation

HRID 2423052 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH2:11][C:12]1[CH:13]=[C:14]([C:19]([F:22])([F:21])[F:20])[CH:15]=[CH:16][C:17]=1[Cl:18]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:11][C:12]1[CH:13]=[C:14]([C:19]([F:20])([F:21])[F:22])[CH:15]=[CH:16][C:17]=1[Cl:18]

Participants

3

Reactant 2

HCID 8475Benzenamine, 2-chloro-5-(trifluoromethyl)-HCID 785722-Chlorobenzimidazole

Product 1

HCID 923997HCID 923997, compound

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 3-amino-4-chlorobenzotrifluoride by Procedure A. The product was isolated upon basic work-up and purified by preparative LCMS to give the title compound as the free base. 1NMR (CDCl3) δ 6.40 (br s, 2H), 7.11-7.15 (d, 1H), 7.18-7.25 (m, 2H), 7.35-7.41 (d, 1H), 7.42-7.46 (m, 2H), 8.57 (s, 1H). MS(ES+) m/z 312 ([M+1]+, 100).

Workup

  1. customThe product was isolated upon basic work-up
  2. custompurified by preparative LCMS

Sources & evidence

ORD record
ord-a83138a6ebee4cd2865c636a1980fd9b
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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