反应详情

A solution of 1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-6-(methyloxy)-1H-indazol-4-ol (D4) (116 mg, 0.32 mmol) in ethanol (5 mL) and ethyl acetate (5 mL) was hydrogenated in an H-cube over a 10% palladium on charcoal catalyst. The resulting solution was concentrated and the product purified by silica gel chromatography eluting with 5-80% ethyl acetate in hexane to yield the title compound (E2) (65 mg).

1. concentrationThe resulting solution was concentrated
2. customthe product purified by silica gel chromatography
3. washeluting with 5-80% ethyl acetate in hexane