HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 136085249, compound → HCID 135910340, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 136085249 | HCID 136085249 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 135910340 | HCID 135910340 | 91.1% |
Reaction Steps
A solution of 6-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazol-4-ol (D8) (470 mg, 1.34 mmol) in ethanol (20 mL) and ethyl acetate (20 mL) was hydrogenated in an H-cube over a 10% palladium on charcoal catalyst. The resulting solution was concentrated to yield the title compound (E4) (320 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960563B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-7d0df55a58204910b2ca83e8e92e4a99 |
| Source note | uspto-grants-2011_06 |