HCID 136085249, compound → HCID 135910340, compound

HRID 2423098Notes

Reaction equation

HRID 2423098 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([OH:26])[C:5]2[CH:6]=[N:7][N:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17]CC4C=CC=CC=4)=[C:13]([F:25])[CH:12]=3)[C:9]=2[CH:10]=1>C(O)C.C(OCC)(=O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([OH:26])[C:5]2[CH:6]=[N:7][N:8]([C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([F:25])[CH:12]=3)[C:9]=2[CH:10]=1

Participants

5

Reactant 1

HCID 136085249HCID 136085249, compound

Product 1

HCID 135910340HCID 135910340, compoundYield 91.1%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 6-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazol-4-ol (D8) (470 mg, 1.34 mmol) in ethanol (20 mL) and ethyl acetate (20 mL) was hydrogenated in an H-cube over a 10% palladium on charcoal catalyst. The resulting solution was concentrated to yield the title compound (E4) (320 mg).

Workup

  1. concentrationThe resulting solution was concentrated

Sources & evidence

ORD record
ord-7d0df55a58204910b2ca83e8e92e4a99
Source dataset
uspto-grants-2011_06
Patent number
US07960563B2

Reaction notes

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