反应详情

A solution of 6-ethenyl-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol (E6) (190 mg, 0.70 mmol) in ethanol (6 mL) and ethyl acetate (6 mL) was hydrogenated over a weekend at room temperature and a pressure of 50 psi over a 10% palladium on charcoal catalyst (20 mg). After filtration to remove the catalyst, the filtrate was concentrated and the crude product purified using MDAP to yield the title compound (E7) (36 mg).

1. filtrationAfter filtration
2. customto remove the catalyst
3. concentrationthe filtrate was concentrated
4. customthe crude product purified