反应详情

A mixture of 1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-3-methyl-4-[(phenylmethyl)oxy]-1H-indazole (D31) (0.45 g) and 10% palladium on charcoal (150 mg) in ethyl acetate (30 mL) was hydrogenated at atmospheric pressure for about 18 hrs. The mixture was filtered, concentrated and chromatographed (silica gel, 0-100% ethyl acetate in hexane) to give the title compound as a white solid (0.15 g) (E15).

1. filtrationThe mixture was filtered
2. concentrationconcentrated
3. customchromatographed (silica gel, 0-100% ethyl acetate in hexane)