反应详情

Pd/C 10 wt. % (0.10 g, 0.094 mmol) was added to a solution of 5-(benzyloxy)-1-(phenylsulfonyl)-1H-indole (Intermediate 7, 6.00 g, 16.5 mmol) and ammonium formate (15.6 g, 248 mmol) in THF/MeOH 1:1 (300 mL). The reaction mixture was stirred overnight at room temperature and filtered through a short plug of silica gel. The filtrate was evaporated and dissolved in DCM and filtered through a plug of silica gel eluating with 2.5% MeOH in DCM. The purest fractions (monitored by TLC) were evaporated to give the title compound (4.2 g) as a white powder. MS m/z 273 [M+H]+.

1. filtrationfiltered through a short plug of silica gel
2. customThe filtrate was evaporated
3. dissolutiondissolved in DCM
4. filtrationfiltered through a plug of silica gel eluating with 2.5% MeOH in DCM
5. customThe purest fractions (monitored by TLC) were evaporated