反应详情

温度

150 °C

To a suspension of 5-(benzyloxy)-6-methoxy-1-(phenylsulfonyl)-1H-indole (Intermediate 14, 6.6 g, 17 mmol) and Pd/C 10 wt. % (2.0 g, 1.9 mmol) in EtOH (30 mL) were cyclohexene (9 mL) and conc. HCl (9 mL) added. The reaction mixture was heated at 150° C. for 5 minutes in a microwave heater. The Pd/C was filtered off and the solvent was removed under reduced pressure to afford the title compound (5.0 g) as a black gum. MS m/z 304 [M+H]+.

1. additionadded
2. filtrationThe Pd/C was filtered off
3. customthe solvent was removed under reduced pressure