反应详情

NBS (32.6 mg, 0.180 mmol) in DMF (1 mL) was added to a solution of 1-(phenylsulfonyl)-1H-indol-5-ol (Intermediate 8, 50.0 mg, 0.183 mmol) in DMF (1 mL) at room temperature. The mixture was stirred for 30 minutes and diluted with water and diethylether and transferred to a separation funnel. The organic phase was washed with water (3×), dried (MgSO4) and evaporated. The crude product was purified by flash chromatography using 10% pentane in DCM as the eluent to give the title compound (50 mg) as a white solid. MS m/z 352/354 [M+H]+.

1. customtransferred to a separation funnel
2. washThe organic phase was washed with water (3×)
3. dry with materialdried (MgSO4)
4. customevaporated
5. customThe crude product was purified by flash chromatography