Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 3,3,3-Trifluoropropanal | HCID 68028 | — |
| Reactant | Sodium Bisulfate | HCID 516919 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 55297838 | HCID 55297838 | — |
Reaction Steps
3,3,3-Trifluoropropanal was added to a mixture of sodium hydrogensulfate and water, with vigorously stirring at 0° C., followed by further stirring for 10 minutes. An aqueous solution of potassium cyanide was dropwise added, followed by reaction with stirring at 0° C. for 1 hour and then work-up and purification to obtain 4,4,4-trifluoro-2-hydroxybutanenitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07960562B2 |
|---|
| Source dataset | uspto-grants-2011_06 |
|---|
| ORD ID | ord-91ac7c6bcede4effa2b3c7bc8bd019d1 |
|---|
| Source note | uspto-grants-2011_06 |
|---|
