Potassium Cyanide → HCID 55297838, compound

HRID 2423232Notes

Reaction equation

HRID 2423232 reaction equation
[F:1][C:2]([F:7])([F:6])[CH2:3][CH:4]=[O:5].S([O-])(O)(=O)=O.[Na+].[C-:14]#[N:15].[K+]>O>[F:1][C:2]([F:7])([F:6])[CH2:3][CH:4]([OH:5])[C:14]#[N:15]

Participants

5

Reactant 3

HCID 9032Potassium CyanideHCID 680283,3,3-TrifluoropropanalHCID 516919Sodium Bisulfate

Product 1

HCID 55297838HCID 55297838, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

3,3,3-Trifluoropropanal was added to a mixture of sodium hydrogensulfate and water, with vigorously stirring at 0° C., followed by further stirring for 10 minutes. An aqueous solution of potassium cyanide was dropwise added, followed by reaction with stirring at 0° C. for 1 hour and then work-up and purification to obtain 4,4,4-trifluoro-2-hydroxybutanenitrile.

Workup

  1. stirringby further stirring for 10 minutes
  2. customfollowed by reaction
  3. stirringwith stirring at 0° C. for 1 hour
  4. custompurification

Sources & evidence

ORD record
ord-91ac7c6bcede4effa2b3c7bc8bd019d1
Source dataset
uspto-grants-2011_06
Patent number
US07960562B2

Reaction notes

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