Trifluoroacetic acid → HCID 86632595, compound

HRID 2423238Notes

Reaction equation

HRID 2423238 reaction equation
FC(F)(F)C(O)=O.[Cl:8][S:9]([C:12]1[C:13]([O:28][CH3:29])=[C:14]([CH:25]=[CH:26][CH:27]=1)[C:15]([O:17]CC1C=CC=CC=1)=[O:16])(=[O:11])=[O:10]>>[Cl:8][S:9]([C:12]1[C:13]([O:28][CH3:29])=[C:14]([CH:25]=[CH:26][CH:27]=1)[C:15]([OH:17])=[O:16])(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86632596HCID 86632596, compound

Product 1

HCID 86632595HCID 86632595, compoundYield 68.7%

Procedure

A trifluoroacetic acid (95 mL) solution of benzyl 3-(chlorosulfonyl)-2-methoxybenzoate (12.9 g) was stirred at 70° C. for 5 hours. The solution part was decanted and evaporated under reduced pressure. Toluene was added to the residue, and this was again evaporated. The resulting solid was collected by filtration, washed with toluene and dried to obtain 3-(chlorosulfonyl)-2-methoxybenzoic acid (6.52 g).

Workup

  1. customThe solution part was decanted
  2. customevaporated under reduced pressure
  3. additionToluene was added to the residue
  4. customthis was again evaporated
  5. filtrationThe resulting solid was collected by filtration
  6. washwashed with toluene
  7. customdried

Sources & evidence

ORD record
ord-4a10d303e2284590af0795b8f45f6cdb
Source dataset
uspto-grants-2011_06
Patent number
US07960562B2

Reaction notes

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