Sodium Hydroxide → HCID 178525939, compound

HRID 2423247Notes

Reaction equation

HRID 2423247 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:5]=[C:6]([C:11](=[O:40])[C:12](=[C:31]2[NH:35][C:34]3[CH:36]=[CH:37][CH:38]=[CH:39][C:33]=3[NH:32]2)[C:13]([C:15]2[CH:16]=[C:17]([S:21]([NH:24][CH2:25][C:26]([O:28]CC)=[O:27])(=[O:23])=[O:22])[CH:18]=[CH:19][CH:20]=2)=[O:14])[CH:7]=[C:8]([F:10])[CH:9]=1>C1COCC1>[F:3][C:4]1[CH:5]=[C:6]([C:11](=[O:40])[C:12](=[C:31]2[NH:32][C:33]3[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=3[NH:35]2)[C:13]([C:15]2[CH:16]=[C:17]([S:21]([NH:24][CH2:25][C:26]([OH:28])=[O:27])(=[O:22])=[O:23])[CH:18]=[CH:19][CH:20]=2)=[O:14])[CH:7]=[C:8]([F:10])[CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178472927HCID 178472927, compound

Product 1

HCID 178525939HCID 178525939, compoundYield 87.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

An aqueous 1 M sodium hydroxide solution (3.1 mL) was added to a THF (10 mL) solution of the compound (300 mg) obtained in Example 2, followed by stirring at room temperature for 3.5 hours. THF was evaporated under reduced pressure, and 1 M hydrochloric acid was excessively added. The precipitate was collected by filtration and dried under reduced pressure to obtain [({3-[3-(3,5-difluorophenyl)-2-(1,3-dihydro-2H-benzimidazol-2-ylidene)-3-oxopropanoyl]phenyl}sulfonyl)amino]acetic acid (250 mg).

Workup

  1. customTHF was evaporated under reduced pressure, and 1 M hydrochloric acid
  2. filtrationThe precipitate was collected by filtration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-ada9827675864185a1ba03402d2f042f
Source dataset
uspto-grants-2011_06
Patent number
US07960562B2

Reaction notes

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