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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2423318Generated: October 26, 2026

Ethyl 2-(3-methoxy-4-(5-nitroquinolin-6-yloxy)phenyl)acetate → Ethyl 2-(4-(5-aminoquinolin-6-yloxy)-3-methoxyphenyl)acetate

https://huagongshe.com/reaction/2423318

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-(3-methoxy-4-(5-nitroquinolin-6-yloxy)phenyl)acetateHCID 59864865—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
ProductEthyl 2-(4-(5-aminoquinolin-6-yloxy)-3-methoxyphenyl)acetateHCID 59864773—

Reaction Steps

Pd/C (30 mg) was added to 24.3 (310 mg) in EtOH (10 mL). The mixture was stirred under hydrogen at room temperature for 6 h. The catalyst was removed by filtration through celite. The filtrate was concentrated under vacuum to give 24.4. MS ESI (pos.) m/z: 353.1 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960567B2
Source datasetuspto-grants-2011_06
ORD IDord-c8724ae8dfef40108eebf9c767ea9de2
Source noteuspto-grants-2011_06