HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Chloro-4-methanesulfonylamino-5-methyl-benzyl)-carbamic acid t-butyl ester → N-(4-Aminomethyl-2-chloro-6-methylphenyl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Chloro-4-methanesulfonylamino-5-methyl-benzyl)-carbamic acid t-butyl ester | HCID 67242868 | — |
| Catalyst | Trifluoroacetic acid | HCID 6422 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-Aminomethyl-2-chloro-6-methylphenyl)methanesulfonamide | HCID 67242390 | 145.8% |
Reaction Steps
(3-Chloro-4-methanesulfonylamino-5-methyl-benzyl)-carbamic acid t-butyl ester (153.8 mg, 0.44 mmol) and CF3COOH (5˜6 drops) were added into methylene chloride. The mixture was stirred for 12 hrs. A reaction solvent was concentrated in vacuo to yield syrup (159.6 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960584B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-8f9be0ee981b4dbf9b8a632280e1990f |
| Source note | uspto-grants-2011_06 |