Hydrochloric Acid → HCID 67243614, compound

HRID 2423342Notes

Reaction equation

HRID 2423342 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([NH:10][S:11]([CH3:14])(=[O:13])=[O:12])=[C:5]([F:15])[CH:4]=1.Cl.[C:17]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]=[CH:28][C:29](O)=[O:30])=[CH:23][CH:22]=1)([CH3:20])([CH3:19])[CH3:18]>>[C:17]([C:21]1[CH:22]=[CH:23][C:24]([CH:27]=[CH:28][C:29]([NH:1][CH2:2][C:3]2[CH:8]=[C:7]([CH3:9])[C:6]([NH:10][S:11]([CH3:14])(=[O:13])=[O:12])=[C:5]([F:15])[CH:4]=2)=[O:30])=[CH:25][CH:26]=1)([CH3:20])([CH3:18])[CH3:19]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 7248384-Tert-butylcinnamic acidHCID 66856249N-(4-Aminomethyl-2-fluoro-6-methyl-phenyl)-methanesulfonamide

Product 1

HCID 67243614HCID 67243614, compoundYield 96%

Procedure

N-(4-Aminomethyl-2-fluoro-6-methyl-phenyl)-methanesulfonamide, and HCl salt (100 mg, 0.35 mmol) were reacted with 3-(4-t-butyl-phenyl)-acrylic acid following the general procedure to give a white solid (140 mg, 96%).

Sources & evidence

ORD record
ord-4353fae46d744d198a7150304ee0c730
Source dataset
uspto-grants-2011_06
Patent number
US07960584B2

Reaction notes

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