(2-Chloro-5-iodo-4-methanesulfonylamino-benzyl)-carbamic acid isopropyl ester → HCID 67244212, compound

HRID 2423349Notes

Reaction equation

HRID 2423349 reaction equation
C(OC(=O)[NH:6][CH2:7][C:8]1[CH:13]=[C:12]([I:14])[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:10][C:9]=1[Cl:20])(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:6][CH2:7][C:8]1[C:9]([Cl:20])=[CH:10][C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[C:12]([I:14])[CH:13]=1

Participants

4

Reactant 1

HCID 67243791(2-Chloro-5-iodo-4-methanesulfonylamino-benzyl)-carbamic acid isopropyl ester

Product 1

HCID 67244212HCID 67244212, compoundYield 130.48%

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidCatalystHCID 6344DichloromethaneSolvent

Procedure

(2-chloro-5-iodo-4-methanesulfonylamino-benzyl)-carbamic acid isopropyl ester (100 mg, 0.22 mmol) was put into a dried 25 ml of round-bottom flask and dissolved in methylenechloride. To the solution were added 5-6 drops of CF3COOH and stirred for 12 hours. After confirming the completion of the reaction with TLC, the resulting solution was concentrated under reduced pressure using toluene to yield a brown syrup (102.1 mg, 130.48%).

Workup

  1. customthe completion of the reaction with TLC
  2. concentrationthe resulting solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f5dd8966ca9c446a97f64fc7f555d258
Source dataset
uspto-grants-2011_06
Patent number
US07960584B2

Reaction notes

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