Hydrochloric Acid → HCID 11851690, compound

HRID 2423354Notes

Reaction equation

HRID 2423354 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[C:7]([F:9])[C:6]([NH:10][S:11]([CH3:14])(=[O:13])=[O:12])=[C:5]([F:15])[CH:4]=1.Cl.C1([O:23][C:24](=O)[NH:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]([CH3:36])([CH3:35])[CH3:34])=[CH:29][CH:28]=2)C=CC=CC=1>>[C:33]([C:30]1[CH:31]=[CH:32][C:27]([CH2:26][NH:25][C:24](=[O:23])[NH:1][CH2:2][C:3]2[CH:4]=[C:5]([F:15])[C:6]([NH:10][S:11]([CH3:14])(=[O:13])=[O:12])=[C:7]([F:9])[CH:8]=2)=[CH:28][CH:29]=1)([CH3:36])([CH3:34])[CH3:35]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 21097524N-(4-Aminomethyl-2,6-difluoro-phenyl)-methanesulfonamideHCID 59389711Phenyl [(4-tert-butylphenyl)methyl]carbamate

Product 1

HCID 11851690HCID 11851690, compoundYield 12%

Procedure

N-(4-Aminomethyl-2,6-difluoro-phenyl)-methanesulfonamide and HCl salt (100 mg, 0.36 mmol) were reacted with (4-t-butyl-benzyl)-carbamic acid phenyl ester following the general procedure to give a white solid (18 mg, 12%).

Sources & evidence

ORD record
ord-baca0e80caaf42c389e168be4dcddd0b
Source dataset
uspto-grants-2011_06
Patent number
US07960584B2

Reaction notes

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