反应详情

温度

65 °C

A solution of 2,4-dichloro-3-pyridinecarbaldehyde (2.15 g, 12.4 mmol) in ethanol (18 mL) was added to a solution of hydroxylamine hydrochloride (1.01 g, 14.5 mmol) and sodium hydroxide (0.58 g, 14.5 mL) in water (9 mL). The resulting solution was heated in a 65° C. oil bath for 3 hours. The mixture was filtered to yield a white solid which was dried in a vacuum oven at 45° C. with P2O5 to yield 2,4-dichloro-3-pyridinecarbaldehyde oxime (1.89 g, 80%). 1H NMR (400 MHz, DMSO-d6): δ 12.00 (s, 1H), 8.35 (d, J=5 Hz, 1H), 8.19 (s, 1H), 7.68 (d, J=5 Hz, 1H).

1. filtrationThe mixture was filtered
2. customto yield a white solid which
3. dry with materialwas dried in a vacuum oven at 45° C. with P2O5