4-Fluorobenzonitrile → 4-(1-Methylpiperidin-4-yloxy)benzaldehyde

HRID 2423566Notes

Reaction equation

HRID 2423566 reaction equation
[OH:1]C1CCN(C)CC1.FC1C=CC(C#N)=CC=1.[CH3:18][N:19]1[CH2:24][CH2:23][CH:22]([O:25][C:26]2[CH:33]=[CH:32][C:29]([C:30]#N)=[CH:28][CH:27]=2)[CH2:21][CH2:20]1>>[CH3:18][N:19]1[CH2:24][CH2:23][CH:22]([O:25][C:26]2[CH:33]=[CH:32][C:29]([CH:30]=[O:1])=[CH:28][CH:27]=2)[CH2:21][CH2:20]1

Participants

4

Reactant 3

HCID 145174-FluorobenzonitrileHCID 660484-Piperidinol, 1-methyl-HCID 114585954-(1-Methylpiperidin-4-yloxy)benzonitrile

Product 1

HCID 234332974-(1-Methylpiperidin-4-yloxy)benzaldehyde

Procedure

Synthesized from 4-hydroxy-1-methylpiperidine and 4-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 4-(1-methylpiperidin-4-yloxy)benzonitrile (500 mg) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (350 mg).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 16

Sources & evidence

ORD record
ord-721afcce5d93434a8c079f279e0c08ed
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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