4-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrile → 4-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde

HRID 2423570Notes

Reaction equation

HRID 2423570 reaction equation
NC(C)(C)C[O:4]C1C=CC(C#N)=CC=1F.[CH3:16][N:17]([CH3:32])[C:18]([CH3:31])([CH3:30])[CH2:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([C:25]#N)=[CH:23][C:22]=1[F:29]>>[CH3:16][N:17]([CH3:32])[C:18]([CH3:31])([CH3:30])[CH2:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([CH:25]=[O:4])=[CH:23][C:22]=1[F:29]

Participants

3

Reactant 2

HCID 230872344-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrileHCID 230874174-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzonitrile

Product 1

HCID 230871524-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde

Procedure

Synthesized from 4-(2-amino-2-methylpropoxy)-3-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 18, 4-(2-dimethylamino-2-methylpropoxy)-3-fluorobenzonitrile (1.4 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (965 mg).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 16

Sources & evidence

ORD record
ord-7cc2337730eb4a5fae32ae28a2627444
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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