Propargyl bromide → 1-(Prop-2-yn-1-yl)piperidine

HRID 2423576Notes

Reaction equation

HRID 2423576 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:7](Br)[C:8]#[CH:9]>C(OCC)C>[CH2:9]([N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[C:8]#[CH:7]

Participants

4

Reactant 2

HCID 7842Propargyl bromideHCID 8082Piperidine

Product 1

HCID 3366521-(Prop-2-yn-1-yl)piperidine

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of piperidine (8.5 ml) in diethyl ether (100 ml) was added propargyl bromide (3 ml) on an ice bath, the solution was stirred overnight at room temperature, then diethyl ether was added thereto followed by filtering, and the solvent was evaporated in vacuo to provide the title compound (6.0 g).

Workup

  1. filtrationby filtering
  2. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-b8720bfdcb834f6293ee484d9c2ea9c9
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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