3-Bromoanisole → (2-Bromo-4-methoxyphenyl)[3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]methanone

HRID 2423588Notes

Reaction equation

HRID 2423588 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([O:8][CH3:9])[CH:5]=[CH:6][CH:7]=1.Cl.[F:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][C:20]=1[O:21][CH2:22][CH2:23][N:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)[C:15](O)=[O:16]>>[Br:1][C:2]1[CH:3]=[C:4]([O:8][CH3:9])[CH:5]=[CH:6][C:7]=1[C:15]([C:14]1[CH:18]=[CH:19][C:20]([O:21][CH2:22][CH2:23][N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)=[C:12]([F:11])[CH:13]=1)=[O:16]

Participants

3

Reactant 2

HCID 169713-BromoanisoleHCID 666268273-Fluoro-4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride

Product 1

HCID 57934302(2-Bromo-4-methoxyphenyl)[3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]methanone

Procedure

Synthesized from 3-bromoanisole (1.1 ml) and 3-fluoro-4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride (3.3 g) according to an analogous synthetic method to Preparation Example 66, the title compound (1.6 g) was obtained.

Workup

  1. customaccording to an analogous synthetic method to Preparation Example 66

Sources & evidence

ORD record
ord-01c66621a53e44f0b121ac949f61287c
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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