Chloromethyl Methyl Ether → Imidazole-4-carboxylic acid, 1-methoxymethyl-, ethyl ester

HRID 242373Notes

Reaction equation

HRID 242373 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:3]=[CH:2]1.Cl[CH2:12][O:13][CH3:14]>>[CH2:9]([O:8][C:6]([C:4]1[N:3]=[CH:2][N:1]([CH2:12][O:13][CH3:14])[CH:5]=1)=[O:7])[CH3:10]

Participants

3

Reactant 2

HCID 7864Chloromethyl Methyl EtherHCID 178469898HCID 178469898, compound

Product 1

HCID 542529Imidazole-4-carboxylic acid, 1-methoxymethyl-, ethyl ester

Procedure

In analogy to Step (1) of Example 1, but using ethyl imidazole-4-carboxylate (26.3 g) and chloromethylmethylether (21.2 mL), the title compound (17.2 g) was afforded.

Sources & evidence

ORD record
ord-5b6bf02830fc4e699c8bff05c1794303
Source dataset
uspto-grants-2014_02
Patent number
US08653126B2

Reaction notes

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