反应详情

The compound (0.750 g) obtained in (2) was dissolved in THF (50 mL), followed by addition of TBAF (1.0 M THF solution, 1.79 mL) under stirring, and the stirring was continued for 1 hour. The reaction solution was concentrated, and the resulting residue was purified by flash chromatography (ethyl acetate/hexane=5%-÷100%) using amino column (product name: Hi-Flash Column 3 L, manufactured by Yamazen Corporation), washed with ethyl acetate/hexane, and subsequently dried to afford the title compound (0.280 g).

1. concentrationThe reaction solution was concentrated
2. customthe resulting residue was purified by flash chromatography (ethyl acetate/hexane=5%-÷100%)
3. washwashed with ethyl acetate/hexane
4. customsubsequently dried