Dichloromethane → HCID 23087516, compound

HRID 2423887Notes

Reaction equation

HRID 2423887 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][N:6]([CH3:14])[C:7](=O)[O:8]C(C)(C)C)[CH3:2].FC(F)(F)C(O)=O.[Cl:22][CH2:23]Cl>>[Cl:22][CH2:23][C:7]([N:6]([CH2:5][CH2:4][O:3][CH2:1][CH3:2])[CH3:14])=[O:8]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57934553HCID 57934553, compound

Product 1

HCID 23087516HCID 23087516, compound

Procedure

To a solution of tert-butyl (2-ethoxyethyl)methylcarbamate (1.2 g) in dichloromethane (6 ml) was added trifluoroacetic acid (6 ml) on an ice bath. The solution was stirred for 30 minutes while warming to room temperature, then the solvent was evaporated in vacuo. Synthesized from the resulting (2-ethoxyethyl)methylamine trifluoroacetate (crude product) (2.3 g) according to an analogous synthetic method to Preparation Example 119, the title compound (799 mg) was obtained.

Workup

  1. customthe solvent was evaporated in vacuo
  2. customSynthesized from the resulting (2-ethoxyethyl)methylamine trifluoroacetate (crude product) (2.3 g)
  3. customaccording to an analogous synthetic method to Preparation Example 119

Sources & evidence

ORD record
ord-e17066bc2f8940349c2d330eb5c8417c
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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