HCID 23087471, compound → HCID 66626414, compound

HRID 2423901Notes

Reaction equation

HRID 2423901 reaction equation
C(N(C1C=C(OC)C=CC=1C1CCC2C(=CC=C(OC)C=2)C1)C(C1C=CC(OCC(O)=O)=CC=1)=O)C.[N:37]1([C:45](=O)[CH2:46][O:47][C:48]2[CH:78]=[CH:77][C:51]([C:52]([N:54]([CH2:75][CH3:76])[C:55]3[CH:60]=[C:59]([O:61][CH3:62])[CH:58]=[CH:57][C:56]=3[CH:63]3[CH2:72][CH2:71][C:70]4[C:65](=[CH:66][CH:67]=[C:68]([O:73][CH3:74])[CH:69]=4)[CH2:64]3)=O)=[CH:50][CH:49]=2)[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]1>>[N:37]1([CH2:45][CH2:46][O:47][C:48]2[CH:49]=[CH:50][C:51]([CH2:52][N:54]([CH2:75][CH3:76])[C:55]3[CH:60]=[C:59]([O:61][CH3:62])[CH:58]=[CH:57][C:56]=3[CH:63]3[CH2:72][CH2:71][C:70]4[C:65](=[CH:66][CH:67]=[C:68]([O:73][CH3:74])[CH:69]=4)[CH2:64]3)=[CH:77][CH:78]=2)[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]1

Participants

3

Reactant 2

HCID 23087471HCID 23087471, compoundHCID 66626037HCID 66626037, compound

Product 1

HCID 66626414HCID 66626414, compoundYield 90.6%

Procedure

Synthesized from {4-{ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]carbamoyl}phenoxy}acetic acid and heptamethyleneimine according to an analogous synthetic method to Example 378, 4-(2-azocan-1-yl-2-oxoethoxy)-N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]benzamide (262 mg) was used according to an analogous synthetic method to Example 337 to provide [4-(2-azocan-1-ylethoxy)benzyl]ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (226 mg). Synthesized from this compound (218 mg) according to an analogous synthetic method to Example 111, the title compound (168 mg) was obtained.

Sources & evidence

ORD record
ord-ac8c6a4b932a4b099ea6d43260228bb3
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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