Resorcinol → 2-hydroxy-4-methoxy-3'-methoxy-benzophenone

HRID 2424183Notes

Reaction equation

[C:1]1(C=CC=C(O)C=1)O.COC1C=C(C=CC=1)C(Cl)=O.[OH:20][C:21]1[CH:26]=[C:25]([OH:27])[CH:24]=[CH:23][C:22]=1[C:28]([C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([O:36][CH3:37])[CH:31]=1)=[O:29].CI>>[OH:20][C:21]1[CH:26]=[C:25]([O:27][CH3:1])[CH:24]=[CH:23][C:22]=1[C:28]([C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([O:36][CH3:37])[CH:31]=1)=[O:29]

Participants

Reactant 4

HCID 5054Resorcinol

HCID 6328Methyl iodide

HCID 74374m-Anisoyl chloride

HCID 11322504HCID 11322504, compound

Product 1

HCID 113228592-hydroxy-4-methoxy-3'-methoxy-benzophenone

Procedure

Synthesized from resorcinol and 3-methoxybenzoyl chloride according to an analogous synthetic method to Preparation Example 66, (2,4-dihydroxyphenyl)(3-methoxyphenyl)methanone (14.7 g) and methyl iodide (9.4 g) were used according to an analogous synthetic method to Example 383 to provide the title compound (10.3 g).

Sources & evidence

ORD record: ord-d0f4004e90be4e5b90daa12cdd2f97a5
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07960412B2

Reaction notes

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