152751-57-0 → 845273-93-0

HRID 2424239Notes

Reaction equation

HRID 2424239 reaction equation
[CH2:1]=[CH:2][CH2:3][NH2:4].[CH2:5]1[O:7][CH:6]1[CH2:8][Cl:9].Cl.[C:11](=[O:14])([OH:13])[O-:12].[Na+]>O>[CH2:1]=[CH:2][CH2:3][NH3+:4].[CH2:5]1[O:7][CH:6]1[CH2:8][Cl:9].[C:11]([O-:14])([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 159247152751-57-0HCID 516892Sodium Bicarbonate

Product 1

HCID 49800084845273-93-0Yield 79.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
62.5 °C

Procedure

Sevelamer hydrochloride (1.1 Kg) was added into 15.5 L solution of sodium bicarbonate (1.1 Kg NaHCO3 in 14.3 L water). The obtained mixture was stirred at 60-65° C. for 4 hrs. The obtained material was filtered by centrifuge filter. The obtained wet cake was added into 15.5 L solution of sodium bicarbonate (1.1 Kg NaHCO3 in 14.3 L water) and stirring was maintained at 60-65° C. for 4 hrs. The material was filtered by centrifuge filter assembly and obtained wet cake was stirred in 11 L water for 1 hr at 60-65° C. The material was filtered by centrifuge filter. The washings of the wet cake with water were repeated thrice at 60-65° C. The obtained wet cake was dried in air tray dryer (ATD) at about 90-100° C. for 30-36 hrs and LOD was checked after every five hours till LOD was in the range of 5 to 10% to get Sevelamer carbonate (0.995 Kg).

Workup

  1. filtrationThe obtained material was filtered by centrifuge
  2. filtrationfilter
  3. additionThe obtained wet cake was added into 15.5 L solution of sodium bicarbonate (1.1 Kg NaHCO3 in 14.3 L water)
  4. stirringstirring
  5. temperaturewas maintained at 60-65° C. for 4 hrs
  6. filtrationThe material was filtered by centrifuge
  7. filtrationfilter assembly
  8. customobtained wet cake
  9. filtrationThe material was filtered by centrifuge
  10. filtrationfilter
  11. customat 60-65° C
  12. customThe obtained wet cake was dried in air tray dryer (ATD) at about 90-100° C. for 30-36 hrs
  13. waitLOD was checked after every five hours till LOD

Sources & evidence

ORD record
ord-a086c3ad09644a69bba1132c11d4fa2b
Source dataset
uspto-grants-2011_06
Patent number
US07964182B2

Reaction notes

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