Chloroacetaldehyde → 4,5,6,7-Tetrahydro-1-benzofuran-4-one

In methanol (40 mL) was dissolved 11.2 g (0.100 mol) of 1,3-cyclohexanedione, an aqueous solution (8 mL) containing 6.60 g (0.100 mol) of 85% potassium hydroxide was added dropwise to the solution, and the resulting mixture was stirred at room temperature for 30 minutes. This mixture was cooled in an ice bath, 21.6 g (0.110 mol) of 40% chloroacetaldehyde aqueous solution was added to the mixture with stirring and the resulting mixture was stirred at room temperature overnight. To the reaction mixture was added dropwise 2 mol/L hydrochloric acid aqueous solution, and the resulting mixture was stirred at room temperature for 30 minutes and extracted with ether. The organic layer was successively washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed, and the obtained residue was purified by silica gel column chromatography (Wako gel C-100, hexane-ethyl acetate, gradient) to obtain 8.63 g (0.0635 mol, Yield: 63.5%) of 6,7-dihydro-1-benzofuran-4(5H)-one.

1. additionwas added dropwise to the solution
2. temperatureThis mixture was cooled in an ice bath
3. stirringwith stirring
4. stirringthe resulting mixture was stirred at room temperature overnight
5. stirringthe resulting mixture was stirred at room temperature for 30 minutes
6. extractionextracted with ether
7. washThe organic layer was successively washed with water and brine
8. dry with materialdried over anhydrous magnesium sulfate
9. customThe solvent was removed
10. customthe obtained residue was purified by silica gel column chromatography (Wako gel C-100, hexane-ethyl acetate, gradient)

ORD record

ord-635d4572e22a45a9af8b58d211bc64e9

Source dataset

uspto-grants-2011_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07964531B2