Sodium Hydroxide → HCID 23677956, compound

HRID 2424326Notes

Reaction equation

HRID 2424326 reaction equation
[OH-].[Na+:2].[Cl:3][C:4]1[N:9]=[N:8][C:7]([O:10][C:11]2[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=2[CH:18]2[CH2:20][CH2:19]2)=[C:6]([OH:21])[CH:5]=1>C(O)C>[Cl:3][C:4]1[N:9]=[N:8][C:7]([O:10][C:11]2[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=2[CH:18]2[CH2:20][CH2:19]2)=[C:6]([O-:21])[CH:5]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178424441HCID 178424441, compound

Product 1

HCID 23677956HCID 23677956, compoundYield 100.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

0.18 mL (0.36 mmol) of 2 mol/L aqueous sodium hydroxide solution was added to an ethanol (2 mL) solution containing 100 mg (0.361 mmol) of 6-chloro-3-(2-cyclo-propyl-6-methylphenoxy)-4-pyridazinol, and the resulting mixture was stirred at 50° C. for 4 hours. The reaction mixture was concentrated to obtain 108 mg (0.361 mmol, Yield: 100%) of sodium 6-chloro-3-(2-cyclopropyl-6-methyl-phenoxy)-4-pyridazinolate (Compound No. 3805).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-23c41a8e4a03421b92e612a399aed769
Source dataset
uspto-grants-2011_06
Patent number
US07964531B2

Reaction notes

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