HCID 13097133, compound → HCID 13097132, compound

HRID 2424337Notes

Reaction equation

HRID 2424337 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]([O:14]CC)=[O:13])[C:6](=[O:17])[CH2:5]2>Cl>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]([OH:14])=[O:13])[C:6](=[O:17])[CH2:5]2

Participants

3

Reactant 1

HCID 13097133HCID 13097133, compound

Product 1

HCID 13097132HCID 13097132, compoundYield 84.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
80 °C

Procedure

In a two neck flask, ethyl (5-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)acetate 58 (0.1 g, 0.39 mmol) was stirred overnight at room temperature in aqueous HCl (6 M, 2 ml) and warmed at 80° C. until disappearance of the starting material by TLC. The reaction mixture was cooled down to room temperature, filtered and the filtrate was washed by cold water to afford (5-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)acetic acid 59 (74 mg).

Workup

  1. temperatureThe reaction mixture was cooled down to room temperature
  2. filtrationfiltered
  3. washthe filtrate was washed by cold water

Sources & evidence

ORD record
ord-f5b88b85662d4b5a881c7d2155122c3b
Source dataset
uspto-grants-2011_06
Patent number
US07964593B2

Reaction notes

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