HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)pyridine-2-carboxylic acid → 3-Trifluoromethyl-pyridine-2-carboxylic acid [3-((S)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)pyridine-2-carboxylic acid | HCID 13233844 | — |
| Reactant | [(S)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl ester | HCID 67234727 | — |
| Product | 3-Trifluoromethyl-pyridine-2-carboxylic acid [3-((S)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide | HCID 53241350 | — |
Reaction Steps
The coupling of [(S)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl ester from experiment F1 (R3=Me) and 3-trifluoromethyl-pyridine-2-carboxylic acid followed by deprotection using procedure H yielded the title compound. MS (ESI): m/z=397.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964594B1 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-b4ec32c8edb34daa8a3d9efdcee5ae81 |
| Source note | uspto-grants-2011_06 |