HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 67246066, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | rel-1-[3-[3-[[(3R,5S)-3,5-Dimethyl-1-piperazinyl]methyl]-1H-pyrazol-1-yl]-2-pyridinyl]-N-(4-fluorophenyl)-4-piperidinamine | HCID 16122912 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67246066 | HCID 67246066 | — |
Reaction Steps
E1 (0.42 g, 0.91 mmol) was taken up in DCM (10 ml) and 1.2M HCl in diethylether (0.76 ml, 0.91 mmol) was added. Removal of the solvent in vacuo yielded the title compound as a yellow solid (0.45 g), δH (DMSO-d6) 1.08 (6H, d), 1.83 (2H, d), 2.07 (2H, br t), 2.72 (2H, t), 2.95 (2H, br d), 3.16 (2H, d), 3.25 (3H, br s), 3.64 (2H, s), 5.38 (1H, br d), 6.45 (1H, s), 6.56 (2H, br s), 6.88 (2H, t), 7.03 (1H, m), 7.69 (1H, d), 8.12 (1H, s), 8.26 (2H, m), 9.09 (1H, br s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964602B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-bbc6d2da7a1f41f592d9d69bd6076907 |
| Source note | uspto-grants-2011_06 |