Hydrochloric Acid → HCID 67246066, compound

HRID 2424423Notes

Reaction equation

HRID 2424423 reaction equation
[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([CH2:9][C:10]2[CH:14]=[CH:13][N:12]([C:15]3[C:16]([N:21]4[CH2:26][CH2:25][CH:24]([NH:27][C:28]5[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=5)[CH2:23][CH2:22]4)=[N:17][CH:18]=[CH:19][CH:20]=3)[N:11]=2)[CH2:3]1.[ClH:35].C(OCC)C>C(Cl)Cl>[ClH:35].[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([CH2:9][C:10]2[CH:14]=[CH:13][N:12]([C:15]3[C:16]([N:21]4[CH2:22][CH2:23][CH:24]([NH:27][C:28]5[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=5)[CH2:25][CH2:26]4)=[N:17][CH:18]=[CH:19][CH:20]=3)[N:11]=2)[CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 16122912rel-1-[3-[3-[[(3R,5S)-3,5-Dimethyl-1-piperazinyl]methyl]-1H-pyrazol-1-yl]-2-pyridinyl]-N-(4-fluorophenyl)-4-piperidinamine

Product 1

HCID 67246066HCID 67246066, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

E1 (0.42 g, 0.91 mmol) was taken up in DCM (10 ml) and 1.2M HCl in diethylether (0.76 ml, 0.91 mmol) was added. Removal of the solvent in vacuo yielded the title compound as a yellow solid (0.45 g), δH (DMSO-d6) 1.08 (6H, d), 1.83 (2H, d), 2.07 (2H, br t), 2.72 (2H, t), 2.95 (2H, br d), 3.16 (2H, d), 3.25 (3H, br s), 3.64 (2H, s), 5.38 (1H, br d), 6.45 (1H, s), 6.56 (2H, br s), 6.88 (2H, t), 7.03 (1H, m), 7.69 (1H, d), 8.12 (1H, s), 8.26 (2H, m), 9.09 (1H, br s).

Workup

  1. customRemoval of the solvent in vacuo

Sources & evidence

ORD record
ord-bbc6d2da7a1f41f592d9d69bd6076907
Source dataset
uspto-grants-2011_06
Patent number
US07964602B2

Reaction notes

Loading…