反应详情

温度

40 °C

A mixture of 5,6-dihydroxyindanone (2.2 g; 13.4 mmol), iodopentane (1.75 ml; 13.4 mmol) and caesium carbonate (Cs2CO3; 4.8 g; 14.7 mmol) in DMF (50 ml) is heated at 40° C. for 35 minutes. The medium is cooled to room temperature, poured into water and extracted with methylene chloride. The combined organic phases are washed with water, dried over sodium sulfate and then concentrated (1.9 g solid). Flash chromatography (85/15 heptane/ethyl acetate) gives the expected product (1.5 g; 48% yield).

1. temperatureThe medium is cooled to room temperature
2. extractionextracted with methylene chloride
3. washThe combined organic phases are washed with water
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated (1.9 g solid)