2,4-Dichlorobenzoyl chloride → HCID 11503319, compound

HRID 2424485Notes

Reaction equation

HRID 2424485 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:12][CH:13]([CH3:31])[CH2:14][CH2:15][NH:16][C:17]([C:19]1[N:20]=[N:21][C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:23][CH:24]=1)=[O:18]>>[CH3:12][CH:13]([CH3:31])[CH2:14][CH2:15][NH:16][C:17]([C:19]1[N:20]=[N:21][C:22]([N:25]2[CH2:30][CH2:29][N:28]([C:4](=[O:5])[C:3]3[CH:7]=[CH:8][C:9]([Cl:11])=[CH:10][C:2]=3[Cl:1])[CH2:27][CH2:26]2)=[CH:23][CH:24]=1)=[O:18]

Participants

3

Reactant 2

HCID 666452,4-Dichlorobenzoyl chlorideHCID 668493226-Piperazin-1-yl-pyridazin-3-carboxylic acid (3-methylbutyl)amide

Product 1

HCID 11503319HCID 11503319, compound

Procedure

Following the procedure of Example 3, making variations only as required to use 2,4-dichlorobenzoyl chloride in place of isoxazole-5-carbonyl chloride to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (3-methylbutyl)amide, the title compound was obtained as a white solid (90% yield). 5H NMR (500 MHz, CS(C13) δ 8.07, 7.85, 7.47, 7.35, 7.28, 7.01, 4.02-4.09, 3.75-3.93, 3.33-3.52, 1.65-1.75, 1.52, 0.94. MS (ES+) m/z 450 (M).

Sources & evidence

ORD record
ord-bb633961e4974426817226763a4df8ff
Source dataset
uspto-grants-2011_06
Patent number
US07964591B2

Reaction notes

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