反应详情

A mixture of the compound obtained in Example 3 (2.3 g; 6.01 mmol), methanol (330 ml), sodium hydroxide (0.96 g; 24 mmol) and water (24 ml) is refluxed for 3 hours. The medium is concentrated to dryness. The residue is taken up in water. The basic aqueous phase is washed with ethyl ether and then acidified with 1N HCl. The cream-coloured precipitate formed is dissolved in methylene chloride. The organic phase is washed with water, dried over sodium sulfate and concentrated (1.5 g; 68% yield).

1. temperatureis refluxed for 3 hours
2. concentrationThe medium is concentrated to dryness
3. washThe basic aqueous phase is washed with ethyl ether
4. customThe cream-coloured precipitate formed
5. washThe organic phase is washed with water
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated (1.5 g; 68% yield)