Methanol → 3-(3-Oxo-6-pentyloxyindan-5-yloxymethyl)benzoic Acid

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Reaction Steps

A mixture of the compound obtained in Example 3 (2.3 g; 6.01 mmol), methanol (330 ml), sodium hydroxide (0.96 g; 24 mmol) and water (24 ml) is refluxed for 3 hours. The medium is concentrated to dryness. The residue is taken up in water. The basic aqueous phase is washed with ethyl ether and then acidified with 1N HCl. The cream-coloured precipitate formed is dissolved in methylene chloride. The organic phase is washed with water, dried over sodium sulfate and concentrated (1.5 g; 68% yield).

Provenance & Evidence