Trifluoroacetic acid → HCID 68444439, compound

HRID 242450Notes

Reaction equation

HRID 242450 reaction equation
[N:1]1([C:7]([C:9]2[CH:10]=[CH:11][C:12]([O:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[C:13]([CH:29]=2)[O:14][CH2:15][C:16]2[CH:17]=[C:18]([CH:26]=[CH:27][CH:28]=2)[C:19]([O:21]C(C)(C)C)=[O:20])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>ClCCl>[N:1]1([C:7]([C:9]2[CH:10]=[CH:11][C:12]([O:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[C:13]([CH:29]=2)[O:14][CH2:15][C:16]2[CH:17]=[C:18]([CH:26]=[CH:27][CH:28]=2)[C:19]([OH:21])=[O:20])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68445213HCID 68445213, compound

Product 1

HCID 68444439HCID 68444439, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound obtained in Example 5 (0.17 g; 0.35 mmol) in dichloromethane (17 ml) is added trifluoroacetic acid (3.4 ml) and the medium is stirred at room temperature for 2 hours. After evaporating to dryness, the residue is crystallized from pentane. The powder is filtered off by suction and dried (0.14 g; 93% yield).

Workup

  1. customAfter evaporating to dryness
  2. customthe residue is crystallized from pentane
  3. filtrationThe powder is filtered off by suction
  4. customdried (0.14 g; 93% yield)

Sources & evidence

ORD record
ord-36863a9f91ef474dbcaf6152ee24838f
Source dataset
uspto-grants-2014_02
Patent number
US08653134B2

Reaction notes

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