5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide → 5-Amino-1-(4,4-difluorocyclohexyl)-1h-pyrazole-4-carboxamide

HRID 2424785Notes

Reaction equation

HRID 2424785 reaction equation
NC1N(C2C=CC=CC=2[O:13]C)N=CC=1C(N)=O.[NH2:18][C:19]1[N:23]([CH:24]2[CH2:29][CH2:28][C:27]([F:31])([F:30])[CH2:26][CH2:25]2)[N:22]=[CH:21][C:20]=1[C:32]#[N:33]>>[NH2:18][C:19]1[N:23]([CH:24]2[CH2:29][CH2:28][C:27]([F:31])([F:30])[CH2:26][CH2:25]2)[N:22]=[CH:21][C:20]=1[C:32]([NH2:33])=[O:13]

Participants

3

Reactant 2

HCID 121517035-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamideHCID 584166835-Amino-1-(4,4-difluorocyclohexyl)-1h-pyrazole-4-carbonitrile

Product 1

HCID 575562475-Amino-1-(4,4-difluorocyclohexyl)-1h-pyrazole-4-carboxamide

Procedure

Following the procedure for the preparation of 5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide but substituting 5-amino-1-(4,4-difluorocyclohexyl)-1H-pyrazole-4-carbonitrile provided the title compound. 400 MHz 1H NMR (CD3OD) δ 8.01 (s, 1H), 4.19 (m, 1H), 2.22-1.90 (m, 8H).

Sources & evidence

ORD record
ord-f4dc4744a05f4deb8d31d5edca11d1ec
Source dataset
uspto-grants-2011_06
Patent number
US07964607B2

Reaction notes

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