5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide → 5-amino-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxamide

HRID 2424787Notes

Reaction equation

HRID 2424787 reaction equation
NC1N(C2C=CC=CC=2[O:13]C)N=CC=1C(N)=O.[NH2:18][C:19]1[N:23]([CH2:24][C:25]([F:28])([F:27])[F:26])[N:22]=[CH:21][C:20]=1[C:29]#[N:30]>>[NH2:18][C:19]1[N:23]([CH2:24][C:25]([F:28])([F:27])[F:26])[N:22]=[CH:21][C:20]=1[C:29]([NH2:30])=[O:13]

Participants

3

Reactant 2

HCID 121517035-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamideHCID 534183335-Amino-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carbonitrile

Product 1

HCID 575562105-amino-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxamide

Procedure

Following the procedure for the preparation of 5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide but substituting 5-amino-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carbonitrile provided the tile compound. 400 MHz 1H NMR (DMSO) δ 7.75 (s, 1H), 7.30 (brs, 1H), 6.78 (brs, 1H) 6.58 (m, 2H), 4.88 (m, 2H).

Workup

  1. customprovided the tile compound

Sources & evidence

ORD record
ord-d24fdc6547d24a4697d83ea09d18151e
Source dataset
uspto-grants-2011_06
Patent number
US07964607B2

Reaction notes

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