5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide → 5-amino-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

HRID 2424803Notes

Reaction equation

HRID 2424803 reaction equation
NC1N(C2C=CC=CC=2[O:13]C)N=CC=1C(N)=O.[NH2:18][C:19]1[N:23]([CH:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[N:22]=[C:21]([CH3:30])[C:20]=1[C:31]#[N:32]>>[NH2:18][C:19]1[N:23]([CH:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[N:22]=[C:21]([CH3:30])[C:20]=1[C:31]([NH2:32])=[O:13]

Participants

3

Reactant 2

HCID 121517035-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamideHCID 17773354HCID 17773354, compound

Product 1

HCID 575562765-amino-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

Procedure

Following the procedure for the preparation of 5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide but substituting 5-amino-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carbonitrile provided the title compound. 400 MHz 1H NMR (CD3OD) δ 4.20 (m, 1H), 4.05 (m, 2H), 3.50 (m, 2H), 2.18 (s, 3H), 2.09 (m, 2H), 1.77 (m, 2H). MS: (M+H m/z 225.0).

Sources & evidence

ORD record
ord-ad5b9bba4f014e0c98096261dd569207
Source dataset
uspto-grants-2011_06
Patent number
US07964607B2

Reaction notes

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